Muscle Extracellular Matrix Scaffold Is a Multipotent Environment

Paola Aulino (1, 2) , Alessandra Costa (3, 1, 4) , Ernesto Chiaravalloti (2) , Barbara Perniconi (5, 2) , Sergio Adamo (1) , Dario Coletti (2, 5) , Massimo Marrelli (2) , Marco Tatullo (2, 6) , Laura Teodori (4, 7)

1 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
2 Calabrodental clinic
3 PITT - University of Pittsburgh
4 Fondazione San Raffaele
5 B2A - Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing
6 Tecnologica Research Institute, Crotone
7 UTAPRAD-DIM, ENEA Frascati

The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differentiation. These results unveil the multipotency of MAS and point to the potential of this new technique as a valuable tool in musculo-skeletal tissue regeneration.

Keywords: ECM scaffold; tissue engineering; skeletal muscle; bone; cartilage

Domains: Human health and pathology

Paola Aulino, Alessandra Costa, Ernesto Chiaravalloti, Barbara Perniconi, Sergio Adamo, et al.. Muscle Extracellular Matrix Scaffold Is a Multipotent Environment. International Journal of Medical Sciences, 2015, 12 (4), pp.336-340. ⟨10.7150/ijms.10761⟩. ⟨hal-01270966⟩